Scientists use embryonic stem cells to create "in vitro follicles"
Scientists use embryonic stem cells to create "in vitro follicles"
It was reported on August 3, 2021 that recently, a research team from Japan developed a reproductive environment simulation system, which can enable mouse pluripotent stem cells to rebuild the ovarian somatic environment. The research was published online in science, entitled "generation of ovarian follicles from mouse pluripotent stem cells". The research team induced the embryonic stem cells of female mice to gradually differentiate by providing different information molecules at different time points, and finally produced a large number of embryonic ovarian somatic like cells (foslcs) similar to ovarian somatic cells. When these foslcs were co cultured with oocytes from mouse embryonic stem cells, foslcs produced an ovarian follicle structure in which oocytes from mouse embryonic stem cells developed into viable eggs. These in vitro generated eggs can be fertilized, and the fertilized eggs are transplanted into the uterus of female mice, and the mice reproduce healthy offspring. This study provides a new technical means for the development of human reproductive medicine and is expected to bring new hope to infertile patients in the future.
Original text: generation of ovarian follicles from mouse pluripotent stem cells